This paper presents the performance enhancement of a double-inlet centrifugal blower by the shape optimization of an impeller. Two design variables, a number of blade and a length of chord, are introduced, and analyzed by a response surface method. Three-dimensional compressible Navier-Stokes equations are used to analyze the blower performance and the internal flow of the blower. Throughout the numerical simulation of the blower, blower efficiency can be increased by reducing separation flow generating from the blade leading edge of a blade pressure surface. It is noted that recirculation flow observed inside the blade passage induces low velocity region, thus increases pressure loss. Efficiency and pressure of the optimum blower are successfully increased up to 3% and 3.9% compared to those of reference blower at the design flow condition, respectively. Detailed flow field inside the blower is also analyzed and compared.