A diesel spray overall SMD (Sauter mean diameter) in a spray chamber was simulated with CFD by varying the compression ratio in the spray chamber from 18:1 to 100:1. The gas densities of the spray chambers for the compression ratios of 18:1 and 100:1 were 17.97 and $74.8kg/m^3$, respectively. Standard KIVA-3V code was used for the CFD simulation. Various fuel injection patterns such as single injection, pilot injection and split injection were used for the CFD simulation. Fuel injection pressures for the simulated diesel sprays are 90 and 120 MPa. As the compression ratio increases, the CFD simulated SMD was decreased, which was generally in agreement with previous experimental studies.