Objectives: The purpose of this study is to examine the factors for self-rated health by gender in South Korean adolescents. Methods: The population consisted of a nationally representative sample of adolescents(n= 37,414 boys, 37,522 girls) in middle and high school who completed the Korea Youth Risk Behavior Web-based Survey(KYRBWS) in 2011. Using logistic regression analysis, self-rated health was regressed on all predictors, including socioeconomic factors, behavioral and psychological factors. All analysis were conducted according to gender. Results: Girls showed more negative self rated health than boys (respectively 28.4%, 40.7%). Adolescent perceptions of health was associated with socioeconomic status, behavioral and psychological factors. Logistic regression analysis revealed that physical activity, body weight perception, despair, level of happiness and stress were the main influencing factors. Conclusions: The findings show that adolescent perceptions of their health are associated with overall sense of functioning, which are associated with health behaviors and psychological factors. Further interventions that focus on improving health behaviors and psychological health may make adolescents more healthy.