Purpose: The purpose of this study was to understand the effect of aquatic exercise on balance and depression of stroke patients. Methods: For 12 participants with stroke, six members of the experimental group and six members of the control group were randomly selected and arranged. Proprioceptive Neuromuscular Facilitation (PNF) lower extremity aquatic pattern exercise was applied to the experimental group. On the other hand, participants in the control group performed PNF lower extremity pattern exercise on the ground. Both exercises were performed 30 minutes per day, five times per week, for a period of six weeks. Balance was assessed using the Berg Balance Scale (BBS) and Timed Up to Go test (TUG). Depression was measured using the Center for Epidemiologic Studies depression scale (CES-D). Results: As a result of comparison within groups, the experimental group showed significant difference for balance and depression after the experiment (p<0.05). In comparison between the two groups, the experimental group in which aquatic exercise was applied showed more significant change in balance and depression than the control group (p<0.05). Conclusion: According to the results of this study, aquatic exercise was proven to enhance the balance and decrease the depression of stroke patients.