Purpose: The purpose of study was to investigate the effects of combination patterns exercise of Proprioceptive Neuromuscular Facilitation (PNF) on unstable surfaces on pain, functional disability, and fear avoidance belief in patients with chronic low back pain. Methods: Twenty four patients were assigned to either the experimental group (n=12) or the control group (n=12). Patients in the experimental group performed combination patterns exercise of PNF on unstable surfaces. Patients in the control group performed combination patterns exercise of PNF on stable surfaces. Both exercises were performed for five days per week, for a period of six weeks. Pain was measured by the Visual Analogue Scale (VAS) and University of Alabama at Birmingham (UAB). Functional disability was measured using the Oswestry Disability Index (ODI) and Roland Morris Disability Questionnaire (RMDQ). Fear avoidance belief was measured using the Fear Avoidance Beliefs Questionnaire (FABQ). A paired t-test was used for determination of differences before and after treatment, and an independent t-test was used for determination of differences between treatment groups. Results: In within group comparison, the experimental group showed statistically significant difference for all variables (p<0.05). In comparison between two groups, the experimental group showed relatively greater significant difference for all variables (p<0.05). Conclusion: Based on such results, it can be said that combination patterns exercise of PNF on unstable surfaces has an effect on pain, functional disability, and fear avoidance belief in patients with chronic low back pain.