Purpose : This study puts the purpose in examining the correlation between the depression of stroke caregivers and their life quality by exploring general characteristics of them and depression. Methods : Questionnaire surveys were conducted on 7 hospitals, located in Busan from August 8, 2011 to September 9, 2011, and 101 copies of questionnaire papers were collected via mail and analyzed. Results : In terms of score ranges of caregivers' depression, a state of non-depression was the majority with a total of 48.5%(N=49), and a state of severe depression was the lowest with 14.9%(N=15). This demonstrated that there would be a significant correlation between depression of stroke caregivers and the quality of their life. In other words, lower scores for depression were associated with higher scores for quality of life while higher depression scores were related with the lower quality of life. As a result of correlation analysis between general characteristics of stroke caregivers and depression, significant differences were found according to genders, ages, the onset duration of patients, health status and diseases of caregivers. Conclusion : In terms of relationship between general characteristics of caregivers and their depression, the higher the age of female caregiver is, the longer the duration of stroke onset is. In this case, caregivers were more depressed than other cases. In addition, as the health status of caregivers was not good and they had disease, they felt more depressed than other times. This study indicates that systematic studies, plans, and development of various programs are required for relieving the depression of stroke patients' caregivers and improving the quality of their life based on this study.