The purpose of this study is to analyze the effect of discrimination experience mediated with self-esteem on the life satisfaction of the severely disabled people and group difference of employment and disability type. For this purpose, the 5th Panel Survey of Employment for the Disabled were used. The subject were adults at the age of 19-64, who were able to participate in the economic activity. Among the respondents, the data of 1,189 of the severely disabled people with physical and mental health were analyzed by AMOS. The major outcomes of the study were as follows. First, the discrimination experience of the severely disabled people had an effect on the life satisfaction by the medium of self-esteem, and this was verified with partial mediated model. Second, there was no difference in the model and path coefficient between the severely disabled people with physical and mental health, while the discrimination experience and self-esteem were predictors of the life satisfaction with two groups. Third, there was a difference of the model and path coefficient between the employment group and the unemployment group. In the case of the employment group, the discrimination experience had an effect on self-esteem, while the discrimination experience and self-esteem did not have effects on the life satisfaction. With the outcomes of this research, the direction of practice for reducing discrimination of the severely disabled people and for increasing the life satisfaction and self-esteem were discussed.