For this study, we developed a STEAM program on Air Pollution, which focuses the control of air pollution and the changes of production processes in Green and Sustainable Chemistry (GSC). This study reports on the results of the applications of the ESD chemistry learning materials, which has been developed by Matsubara for the chosen university. This study reports on the results of the applications of the ESD chemistry learning materials, which has been developed by Matsubara for the chosen university. The results of the research obtained in this study are as follows: Based on the analysis of the contents of WS 1, WS 2, and WS 3, it was found that they were correctly aware of the contents on the basis of the classes and the reference materials.