The purpose of this study is to examine the effect of the music therapy using tone chimes on self-esteem and interpersonal relation of multicultural adolescents. Music therapy session using tone chimes, which includes playing melody, harmony, 2 parts, and 3 parts ensemble, was organized and operated based on using music that is familiar to adolescents from pop music to Original Sound Track and classic music. The subjects of this study were selected from M foreign school in Seoul. Of 20 participants, 10 were randomly assigned into an experimental group, and the other 10 were assigned into a control group. The SPSS 20.0 program was utilized for data analysis of the results of following tests: Mann-Whitney U, Ranked ANCOVA, and Wilcoxon matched-pairs signed-ranks. The result of this research is below. First, adolescents in experimental group who participated in the music therapy with tone chimes showed statistically significant difference in self-esteem. Second, adolescents in experimental group who participated in the music therapy with tone chimes showed statistically significant difference in interpersonal relation. By showing the positive result of the music therapy with tone chimes in self-esteem and interpersonal relation of multicultural adolescents, this study affirms the music therapy with tone chimes not only as an effective way to support intercultural adolescents both socially and emotionally, but also as a practical therapeutic method which can be applicable to a school setting.