A cognitive-behavioral approach integrates two main perspectives of human behavior, behavioral and cognitive theories. By incorporating both cognitive and behavior training strategies, the cognitive-behavioral training approach has been effective at increasing not only skill acquisition, but also generalization of treatment effects. Evidence of the effectiveness of the cognitive-behavioral training approach for individuals with disabilities is examined through: (a) an overview of the theoretical foundations of the cognitive-behavioral approach to intervention and (b) a literature review of intervention studies that have investigated the effects of self-instructional training, which is a cognitive-behavioral approach, for individuals with mental retardation and/or developmental disabilities. Theoretical assumptions of the cognitive-behavioral training approach and characteristics of self-instructional training are also presented. Next, a literature review of selfinstructional studies is described, focusing primary on self-instructional training components and generalization effects of self-instruction. Finally, this paper concludes by presenting a discussion of research findings and recommendation for future research.