The development of good arch form, the orientation of the dentition with relation to the craniofacial skeleton and the establishment of correct relationship of axial inclination of upper and lower teeth are required in normal occlusion, but different teeth present different degrees of axial inclination. The purpose of this study was to investigate the axial inclination of upper and lower teeth by analyzing 45° oblique and 90° cephalometric roentgenograms of 35 Korean males and 34 females with normal occlusion. The obtained results were as follows: 1. Mean and standard deviation of mesiodistal axial inclination of upper and lower teeth related to palatal plane and occlusal plane were obtained. 2. Mesiodistal axial inclination of upper first premolar was nearly perpendicular to palatal plane, and the axis of lower first premolar was nearly perpendicular to occlusal plane. 3. There was no difference in the mesiodistal axial inclination of anteriorly positioned teeth between the three groups: third molar eruption into good alignment (Group 1), third molar impaction or partial eruption (Group 2), third molar agenesis (Group 3). 4. There were low correlationships only between the axial inclination of central incisor and the mesiodistal axial inclination of canine and first premolar, but no correlationships between central incisor and posterior teeth behind first premolar.