The purpose of this research is to investigate the correlation between outpatients in psychiatric clinic with their mental health and family factors. One-hundred and sixty-two patients, who are over twenty-eight years old and is below seventy-eight year were chosen as subjects of research and was surveyed off-line. One-hundred and forty-nine surveys were used for as-built analysis excluding thirteen surveys that were answered earnestly. For measuring, SCL-90-R, FILE, and FACES-IV were used in the current study. Data analysis was performed using Pearson correlation analysis and Process macro using SPSS 22.0. The results of this study are as follows. There was no significant correlation between SCL-90-R and family stress, SCL-90-R, and family cohesion and family adaptability, but family stress, family cohesion and family adaptability were significantly correlated(r(149)=.354, p<.01). In addition, the analysis showed significant mediating effects of family cohesion and adaptation on connection and adaptation factors of family stress, finance and health variables on mental health. Professional relationship were found to have a significant effect on mental health through connection factors. This study is meaningful in that family stress, family cohesion and adaptive ability were found to have major correlation and mediating effects on the family factors of psychiatric outpatients.