The purpose of this study was to investigate the degree of self-efficacy and academic stress related to college life adjustment in college students and to identify predictive factors influencing college life adjustment and sub components. Data were collected through self reported structured questionnaire from 191 nursing using convenient sampling methods from June 1 to 15, 2017. Data were analyzed using SPSS WIN/PC 22.0 by means of descriptive statistics, Pearson coefficient correlation and multiple regression. The average score of self-efficacy, academic stress and adjustment to college life was 2.95, 2.81 and 3.28 respectively There were positive correlations among satisfaction in major, self-leadership, and career preparation behavior. The higher the level of self-efficacy, the lower the academic stress, the better the adaptation to college life. These variables together explained 24% of the adjustment to college life in nursing student(F= 11.49, p< .001) As for the sub-variables, the excellence of the major was statistically significant with both the self-efficacy and the academic stress, and showed a high explanatory power of 27.8%(F= 15.64, p<.001). In conclusion, nursing college students need to develop and support programs to improve academic stress coping ability and self efficacy