Purpose: The purpose of this study was to investigate the effects of self awareness, other awareness, and communication ability of nursing students on interpersonal relation. Methods: The subjects of this study were nursing college students attending a 4th grade university in B city, For data collection 97 nursing students completed self-report questionnaires. Data were analyzed using frequency, percentage, Pearson’s correlation coefficients, and stepwise multiple regression. Results: Self-awareness, other-awareness, communication ability and interpersonal relation of the participants showed moderate levels. There were significant positive correlations between interpersonal relation and communication ability (r=.42, p<.001). Communication ability and self-awareness were significant factors, which explained about 21.7% of the variance in interpersonal relation. Conclusion: These findings suggest that nursing students need to have the ability to recognize their own needs and their ability to recognize and solve various problems of communication and interpersonal relationships in an effective clinical nursing intervention to relieve anxiety and tension in the clinical practice field. So, this study is thought to have important significance.