The purpose of this study was to investigate how Independent living education be linked with role-making effects on self-esteem, career attitude of college with developmental disabilities(DD). 33 students with DD, 1st grade 21, 2nd grade 3, 3rd grade 8 and 4th grade 1 in N university, in Independent living education class, participated in this study which include surveys and interviews. This study was one-group pretest-posttest design. A descriptive statistics and t-test approaches were used to investigate the general information and the difference between the pretest and posttest. It was employed to analyze correlation between self-esteem and career attitude by SPSS(VER.20) and Interviews by constant comparative method. The finding of this study is as follows. First, Self-esteem of students with DD was improved. Second, students with DD show better awareness about career attitude. Third, the correlation between self-esteem and career attitude was also statistically significant. Finally, although DD students may encounter difficult tasks and failure, this study show that role-making in independent living education can afford opportunities on how to handle the emotional arousal positively. These findings further suggest that functional educational curriculum linked with real life including successful experiences should be more invigorated on educations of college students with DD.