The subjects of this study were 809 students who attended the MLST learning strategy test from 2015 to 2017 in A university in Seoul. To investigate the students mastery goal and learning strategy according to the level of self-efficacy score of college students, the students were divided into 2 groups respectively. The high self-efficacy group is the top 30% of the self-efficacy score, and the low self-efficacy group is the bottom 30% of the self-efficacy score. In order to explore the self-efficacy and learning strategies of college students according to mastery goals, students belonging to the top 30% of the mastery goal were classified as high and the students belonging to the bottom 30% were classified as low. The independent sample t-test was conducted to analyze differences in performance approach goal and learning strategies according to achievement goal orientation and learning strategy difference and to analyze self-efficacy and learning strategies according to the mastery goal of college students. As a result, the high self-efficacy group showed higher mastery goal and performance approach goal score than the low group, and scores of all sub-factors of learning strategy were higher. The high mastery goal group showed higher scores in self-efficacy, performance approach goal, and learning strategy than the low group.