The purpose of this study was to investigate the effect of interaction with mothers by performing art therapy for children with autism spectrum disorders who have exhibited difficulties with social communication and interaction. The subject A, is an 8-year-old boy who was officially diagnosed with a second-degree autistic disorder before age 3., The program consisted of 15 sessions that were 50 minutes each. A underwent one or two sessions per week from August 2020 to October 2020. The Marschak Interaction Method Rating Scale (MIM-RS) was used as the pre- and post-test to analyze the data, and the Marschak Behavior Rating Scale (MBRS) was employed for measuring the degree of the interaction in each session. The results of the analysis were as follows. First, art therapy was found to positively affect the interaction between children with autism spectrum disorder and their mothers. The overall interaction was improved in the sub- region of the MIM RS. Second, positive changes occurred in the mother-child interactions through art therapy in the process of each session. As a result of MBRS, the mother showed relatively stable interactions with the child over the course of the session. A had ups and downs depending on the art media, but overall, A’s interactions improved under the balanced control of his mother. Based on these findings , the significance and limitations of this study were then discussed.