Tissue remodeling follows the initial phase of wound healing and stops inflammatory and scar-forming processes, then restores the normal tissue morphology. The human peptide Gly-(L-His)-(L-Lys) or GHK, has a copper 2+ (Cu2+) affinity similar to the copper transport site on albumin and forms GHK-Cu, a complex with Cu2+. These two molecules activate a plethora of remodeling related processes: (1) chemoattraction of repair cells such as macrophages, mast cells, capillary cells; (2) anti-inflammatory actions (suppression of free radicals, release of oxidizing iron, blocking ultraviolet damage to skin keratinocytes and improving fibroblast recovery after X-ray treatments); (3) increases protein synthesis of collagen, elastin, metalloproteinases, anti-proteases, fibroblast growth factor 2,; (4) increases the proliferation of fibroblasts and keratinocytes; and hair follicle size. GHK-Cu stimulates wound healing in numerous models and in humans. Controlled studies on aged skin demonstrated that it tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photodamage and hyperpigmentation. GHK-Cu also improves hair transplant success, protects hepatic tissue from tetrachloromethane poisoning. EAA and water soluble propolis act well as antioxidant/antimicrobial materials on skin. Especially water soluble propolis showed radioprotective effects. As well as EAA and propolis related processes anti-inflammatory actions. Therefore, the human scalp anti-ageing and anti-hair loss can control by above materials.