The holisitic thought is the best idea and have an important effect on her or his life. The reason is that the purpose and goal of the holism is life itself. Can we answer without hesitation that question such as "how want to feel and live" or "are you happy"? We could not answer to essential problems of the life by reason that we overlook an important matter on real life, and so we have been spend to feel trouble and thirst. But we cannot endure no more such as trouble or thirst and do not spare any efforts to discover for a means of settling. In the efforts it attract our attention to change of the education. Particularly, special education has been resistant to fundamental change because of starting points for the special education, the stronger dose formula, the orthodox medical model, the education for All Handicapped Children Act P.L.94-142. The holism appear to solve this kind of problems, and dose it's best to adequate individual unique needs to be in harmony with the whole. In the chain of effects holism establish holistic assumptions and presentation holistic learning principle. The holistic assumptions are followed : (1)the epistemic nature of reality and knowing, (2)whole-part-whole relationships, (3)inherent order within complexity, (4)change and progress are transformative, (5)immanent activity, purposefulness, goal-directedness, self-organization, and self-regulation, (6)the organism is an open, living system, always in exchange with it's environment and it's history, (7)illustrations of self-organization, intentionality purpose and goal-directedness. And holistic learning principles are followed : (1)learning is immanently active, (2)learning is understanding relations, (3)change and progress are transformative, (4)much learning occurs though social exchange with persons and symbols, (5)assessment equals documentation of authentic learning process and learning outcomes, (6)errors are essential and positive activities and should never be punished, (7)trust and authenticity between teacher and student are essential. The apt teaching-learning methods with holistic learning principles are adaptive teaching, cooperative learning, a peer tutoring learning. And creative education is important more than ever to development for individual unique characters and latent faculties. The education of 21 century go into throughly human nature with creative, cooperative and happy. The holism have an important effect on general changes.