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전체 선택해제
총 115건 검색
본문검색 결과만 보기
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Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice
Arash Minai-Tehrani, Young-Chan Park, Soon-Kyung Hwang, Jung-Taek Kwon, Seung-Hee Chang, Sung-Jin Park, Kyeong-Nam Yu, Ji-Eun Ki 대한수의학회 Journal of Veterinary Science 9 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 4호 2 309-317 (9 pages)
Conventional lung cancer therapies are associated with poor survival rates; therefore, new approaches such as gene therapy are required for treating cancer. Gene therapies for treating lung cancer patients can involve several approaches. Among these, aerosol gene delivery is a potentially more effective approach. In this study, Akt1 kinase-deficient (KD) and wild-type (WT) Akt1 were delivered to the lungs of CMV-LucR-cMyc-IRES-LucF dual reporter mice through a nose only inhalation system using... -
Pre- and post-operative cardiac evaluation of dogs undergoing lobectomy and pneumonectomy
Meri? Kocat?rk, Hakan Salci, Zeki Yilmaz*, A. Sami Bayram, Jørgen Koch 대한수의학회 Journal of Veterinary Science 8 Pages
대한수의학회 Journal of Veterinary Science 2010, 제 11권 제 3호 12 257-264 (8 pages)
This study aimed to assess the influence of lobectomy and pneumonectomy on cardiac rhythm and on the dimensions and function of the right-side of the heart. Twelve dogs undergoing lobectomy and eight dogs undergoing pneumonectomy were evaluated preoperatively and one month postoperatively with electrocardiography and Doppler echocardiography at rest. Pulmonary artery systolic pressure (PASP) was estimated by the tricuspid regurgitation jet (TRJ) via the pulse wave Doppler velocity method.... -
Identification and prevalence of Ehrlichia chaffeensis infection in Haemaphysalis longicornis ticks from Korea by PCR, sequencing and phylogenetic analysis based on 16S rRNA gene
Seung-Ok Lee, Dong-Kyeun Na, Chul-Min Kim, Ying-Hua Li, Yoon-Hee Cho, Jin-Ho Park, John-Hwa Lee, Seong-Kug Eo, Terry A. Klein, J 대한수의학회 Journal of Veterinary Science 5 Pages
대한수의학회 Journal of Veterinary Science 2005, 제 6권 제 2호 10 151-155 (5 pages)
Genomic DNAs extracted from 1,288 Haemaphysalis longicornis ticks collected from grass vegetation and various animals from nine provinces of Korea were subjected to screening by genus-specific (Ehrlichia spp. or Anaplasma spp.) real-time TaqMan PCR and speciesspecific (E. chaffeensis) nested-PCR based on amplification of 16S rRNA gene fragments. In all, 611 (47.4%) ticks tested positive for genus-specific amplification of 116 bp fragment of 16S rRNA of Ehrlichia spp. or Anaplasma spp.... -
Prosthetic and Orthodontic Treatment of Adult Patients with a Unilateral Cleft Lip and Palate: Two Clinical Reports
Sung-Hwan Choi, Young-Soo Jung, Chung-Ju Hwang 대한구순구개열학회 대한구순구개열학회지 10 Pages
대한구순구개열학회 대한구순구개열학회지 2019, 제 22권 1호 3 11-20 (10 pages)
Adult cleft lip and/or palate (CL/P) patients with a maxillomandibular skeletal discrepancy and missing teeth require an interdisciplinary approach for esthetic satisfaction. The prosthetic and orthodontic treatments for two unilateral CL/P patients with 2 different prostheses and orthodontic interventions are described. A 20-year-old woman with a skeletal Class II, anterior open bite, and the missing teeth was treated with zirconia-based fixed dental prostheses after orthodontic treatment with... -
Effect of glucose level on chemical hypoxia- and hydrogen peroxide-induced chemokine expression in human glioblastoma cell lines
YieunJung, So-HeeAhn, SangHuiPark, Youn-HeeChoi 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.5 6 509-518 (10 pages)
Glioblastoma multiforme (GBM) is the most common primary intracranial tumor in adults and has poor prognosis. The GBM-specific tumor microenvironment (TME) plays a crucial role in tumor progression, immune escape, local invasion, and metastasis of GBM. Here, we demonstrate that hypoxia, reactive oxygen species (ROS), and differential concentration of glucose influence the expression of cytokines and chemokines, such as IL-6, IL-8, and IP-10, in human glial cell lines. Treatment with cobalt... -
Amelioration of Bleomycin-induced Pulmonary Fibrosis of Rats by an Aldose Reductase Inhibitor, Epalrestat
XianweiLi, YuanyuanShen, YiningLu, JierenYang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 12 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2015, Vol.19 No.5 2 401-412 (12 pages)
Aldose reductase (AR) is known to play a crucial role in the mediation of diabetic and cardiovascular complications. Recently, several studies have demonstrated that allergen-induced airway remodeling and ovalbumin-induced asthma is mediated by AR. Epalrestat is an aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. Whether AR is involved in pathogenesis of pulmonary fibrosis and whether epalrestat attenuates pulmonary fibrosis remains unknown.... -
Oxidatvive Stress in Rat Model of Preeclampsia and Clinical Correlates
Yuk-JaeChang, Won-KiLee, Hyung-GunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2007, Vol.11 No.3 8 129-133 (5 pages)
There are growing evidences suggesting a pivotal role of oxidative stress in the pathophysiology of preeclampsia. We investigated oxidative stress in the rat model of preeclampsia, and in clinical cases. Pregnant female rats were injected intraperitoneally with deoxycorticosterone acetate (DOCA) and given 0.9% saline as drinking water during their pregnancy. We assessed plasma F2-isoprostane (8-iso-PGF2α) and malondialdehyde (MDA) in a rat model, and the same markers in the plasma of maternal... -
도시 지역 알쯔하이머형 치매 환자를 대상으로 한 한국판 MMSE(MMSE-K)의 진단적 타당성 조사와 정신병리 평가
김민걸, 이상수, 이영호, 이상경, 안동성, 윤성환, 심주철, 김용관, 김영훈 대한신경정신의학회 신경정신의학 15 Pages
대한신경정신의학회 신경정신의학 1998, 제 37권 제 6호 26 1277-1291 (15 pages)
연구목적： 본 연구는 ① 도시거주 노인환자들을 대상으로 알츠하이머형 치매의 진단에 있어서의 MMSE-K의 진단 적 타당성을 조사하고, 비치매 환자들과의 감별에 있어서의 MMSE-K 소항목별 민감도와 특이도를 평가하 여 이 평가척도의 임상적 유용성을 검증하고, ② 도시거주 알츠하이머형 치매 환자들의 정신증상의 발생빈도 를 알아보고, 인지기능의 장애정도와 정신병리의 심한 정도와의 상관성을 조사하고자 기획되었다. 방 법： 연구대상자는 치매환자 무료진료시 수진한 총 107명의 도시거주 55세이상의 노인들이었다.... -
한국판 세계보건기구 삶의 질 척도(WHOQOL)의 개발
민성길, 김광일, 서신영, 김동기 대한신경정신의학회 신경정신의학 11 Pages
대한신경정신의학회 신경정신의학 2000, 제 39권 제 1호 8 78-88 (11 pages)
연구목적： 본 연구는 세계보건기구에서 개발한 세계보건기구 삶의 질 척도(WHOQOL：World Health Organization Quality of Life assessment instrument)를 한국어로 번역하고 그 타당도 및 신뢰도를 검증하는 것이다. 방 법： WHO의 지침에 따라 영문판 WHOQOL을 한국어로 번역하고 응답점 설정작업을 한후, 일반인 및 전문가 초점 그룹으로 하여금 검토 수정하였다. 이를 영문으로 다시 재 번역하여 WHO의 검토를 받고 다시 수정하 였다. 이 한국어판을 정상인, 의학적 환자, 그리고 대학생 등 583명을 대상으로 평가하게 하여,...
