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본문검색 결과만 보기
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Baduk (the Game of Go) Improved Cognitive Function and Brain Activity in Children with Attention Deficit Hyperactivity Disorder
SeHee Kim, DougHyun Han, YoungSik Lee, BungNyun Kim, JaeHoon Cheong, SangHo Han 대한신경정신의학회 Psychiatry Investigation 9 Pages
대한신경정신의학회 Psychiatry Investigation 2004, 제 11권 제 2호 7 143-151 (9 pages)
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The grading of cognitive state comparisons with different distances across three conditions in stroke survivors
Yu-mi Kim, Yu-hyung Park 물리치료재활과학회 Physical Therapy Rehabilitation Science 8 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 2호 9 134-141 (8 pages)
conditions in stroke survivors with the grading of cognitive state. Design: Cross-sectional study. Methods: Twelve stroke patients who agreed to active participation were included. Participants were allotted to normal cognitive (CN) group (n=7) and cognitive impairment (CI) group (n=5) and then walked on a self-paced walkway at three conditions on the Time Up and Go (TUG) test and the 6 minute walk test (6MWT): 1) walking with your comfortable speed, 2) walking while carrying a tray with glasse... -
Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)
Tomohiro Kondo, Suguru Yoshida, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Takayuki Nakajima, Ken Takeshi Kusakabe, Tosh 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 5 505-511 (7 pages)
At 5 and 10 days after BCCAO, extensive neuronal cell death was observed in the hippocampal CA1 region. Cognitive performance was evaluated by using the radial maze and passive avoidance tests. In the radial maze test, which examines win-stay performance, the number of errors was significantly higher in ischemic gerbils than in sham-operated gerbils on days 1 and 2 post-operation. In the passive avoidance test, the latency and freezing times were significantly shorter in ischemic gerbils than in... -
Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models
KiYoungShin, KaYoungKim, Yoo-HunSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 7 55-64 (10 pages)
cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. Moreover, DHED significantly improved learning and... -
A Neuropsychological Study of Executive Function Deficit in Autistic Disorder
Min-Sup Shin, Hye-Geun Park, Kang Hong 대한신경정신의학회 신경정신의학 10 Pages
대한신경정신의학회 신경정신의학 2002, 제 41권 제 6호 10 1059-1068 (10 pages)
연구목적： 본 연구에서는 자폐 장애 아동들의 보이는 실행기능 결함과 마음 이론의 결여에 대해 신경심리학적으 로 규명해보고자 하였다. 방 법： 11세에서 15세 연령 범위의 자폐 장애 아동 14명(남아 12, 여아 2), 정신 지체 아동 12명(남아 11, 여아 1), 그리고 정상 아동 14명(남아 12, 여아 2), 총 40명의 아동이 본 연구에 참여하였다. 모든 아동 들에게 마음 이론을 평가하는“샐리-앤”과제와 실행 기능을 평가하는 세가지 신경심리검사를 개별적으 로 실시한 후, MANOVA와 Chi-Square 분석을 실시하여 집단간 차이를... -
뇌졸중 환자를 대상으로 실시한 비문해 노인 특성반영 인지기능검사 (Literacy Independent Cognitive Assessment; LICA)와 한국판 몬트리올 인지평가(Korean version of Montreal Cognitive Assessment; MoCA-K)의 상관관계
장태용, 이연주 고령자치매작업치료학회 고령자·치매작업치료학회지 10 Pages
고령자치매작업치료학회 고령자·치매작업치료학회지 2019, 제 13권 제 1호 10 91-100 (10 pages)
목적 : 본 연구는 뇌졸중 환자를 대상으로 노인 인지기능검사(LICA)의 타당성을 알아보기 위해 MoCA-K와의 상관관계를 실시하였다. 연구방법 : 2018년 5월 1일부터 2018년 9월 30일까지 서울 소재의 병원에서 뇌졸중으로 입원한 환자를 30명을 대 상으로 LICA, MoCA-K 평가하였다. 연구결과 : LICA와 MoCA-K의 수행 점수간의 상관계수는 r=.469로 통계적으로 유의미한 차이를 보였다. MoCA-K 의 학력과의 상관관계는 r=.760로 유의미한 차이를 보였으며 LICA는 학력과의 상관관계는 r=.432로 유의미한 차이를 보였다. MoCA-K하위 항목... -
Effect of Environmental Enrichment on Cognitive Impairment-induced by Ethanol Exposure in Adolescent Rat
Yoon Ju Kim, Jong Min Park, Min Kyung Song, Ho Hyun Seong, Youn Jung Kim 한국기초간호학회 Journal of Korean Biological Nursing Science 6 Pages
한국기초간호학회 Journal of Korean Biological Nursing Science 2016, Volume 18, No 4 10 274-279 (6 pages)
on cognitive function. Environmental enrichment ameliorates the cognitive function and increases neurotrophins. Thus, we investigated the neuroprotective effect of environmental enrichment on ethanol induced cognitive impairment in adolescent rats. Methods: The ethanol groups and the controls groups were injected with ethanol (0.5g/kg) and phosphate buffered saline, respectively, through intraperitoneal from 28th day of birth for 11 days. The environmental enrichment groups were provided larger... -
Development and Usability of a Cognitive Rehabilitation System Based on a Tangible Object for the Elderly
Park Sangmi, Won Kyung-A, Shin Yun-Chan, Park Ji-Hyuk 대한신경계작업치료학회 재활치료과학 12 Pages
대한신경계작업치료학회 재활치료과학 2019, 제 8권 1호 4 51-62 (12 pages)
cognitive rehabilitation system with diverse cognitive functional levels based on tangible objects for the elderly population. Methods: A study was conducted to investigate the system s strengths and weaknesses by upgrading it with responses from two groups of 15 patients and 4 occupational therapists. After undergoing three forms of training - regarding executive function, memory, and concentration for a total of 20–30 min, the participants were asked to answer a structured questionnaire... -
Virtual Reality in Cognitive Rehabilitation
Park Inn-Jee, O.D., Park Heung-Seok, M.S., O.T., Kim Tae-Hoon, M.P.H., O.T. 대한신경계작업치료학회 재활치료과학 10 Pages
대한신경계작업치료학회 재활치료과학 2012, 제 1권 1호 3 29-38 (10 pages)
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Empathy and Intersubjectivity in Culture: From studies on Young Children with Attention Deficit/Hyperactivity Disorder (ADHD) (ppt)
Kyunghwa Lee 환태평양유아교육연구학회 Pacific Early Childhood Education Research Association Annual Conference 25 Pages
환태평양유아교육연구학회 Pacific Early Childhood Education Research Association Annual Conference 14th 9 393-417 (25 pages)
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Empathy and Intersubjectivity in Culture: From Studies of Young Children with Attention Deficit/Hyperactivity Disorder (ADHD)
Kyunghwa Lee 환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 19 Pages
환태평양유아교육연구학회 Asia-Pacific journal of research in early childhood education 2014, Vol.8 No.2 3 27-45 (19 pages)
Drawing on studies of young children with Attention Deficit/Hyperactivity Disorder (ADHD) that I have conducted, I discuss in this article my developing ideas about empathy and intersubjectivity in culture. I begin by briefly explaining why I have studied young children with ADHD. I share some findings from a cross-cultural study of early childhood teachers’ perspectives on ADHD that I conducted a few years ago. I then describe peer relations of children with ADHD based on both a review of... -
Are Teacher Ratings and Parent Ratings Differently Associated with Children’s Intelligence and Cognitive Performance?
SooChurl Cho, HyoWon Kim, BoongNyun Kim, MinSup Shin, HeeJeong Yoo, JaeWon Kim, SooYoung Bhang, InHee Cho 대한신경정신의학회 Psychiatry Investigation 7 Pages
대한신경정신의학회 Psychiatry Investigation 2011, 제 8권 제 1호 3 15-21 (7 pages)
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The effect of visual information on gait parameters with induced ankle muscle fatigue
Hye Rim Suh, Jin-Hee Hwang, Su-Young Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 3호 6 140-145 (6 pages)
Objective: The purpose of this study was to investigate the effect of visual block with ankle joint fatigue on gait and dynamic balance ability. Design: Cross-sectional study. Methods: Thirty healthy young adults (men=15, women=15) between 22 to 25 years of age voluntarily participated in this study. All subjects performed the gait and dynamic balance test successively in two conditions: the visual block and the open eyes condition. Before the gait and dynamic balance test, muscle fatigue on the... -
Effect of upper extremity coordination exercise during standing on the paretic side on balance, gait ability and activities of daily living in persons with stroke
Ju-O Kim, Byoung-Hee Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2017, 제 6권 제 2호 1 53-58 (6 pages)
Objective: The purpose of this study was to determine the effect of upper extremity coordination exercise (UECE) during standing on the paretic side on balance, gait ability and activities of daily living (ADL) in persons with stroke. Design: A randomized controlled trial. Methods: A total of 27 patients with hemiplegic diagnosis after stroke were divided into two groups. Fourteen patients were in the study group and 13 patients were in the control group. The study group received conventional... -
Relationship between anticipatory postural adjustment of the trunk, dual tasks and physical performance with chronic stroke survivors
Won Jeong Hwang, Min Kwon Cho, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2015, 제 4권 제 1호 8 44-48 (5 pages)
Timed Up and Go (TUG) test. The dual tasks were the TUGconitive, which increased cognitive capacity, and the TUGmanual task, which had an external focus. Results: All EMG data showed earlier onset latency before the prime mover. In affected leg raising, the onset time of unaffected ES muscle of the stroke patients was correlated with the single and dual tasks (p<0.05). In unaffected leg raising, the onset time of the affected IO muscle was related to all the tasks (p<0.05). Gait speed showed a... -
Effects of 3-dimensional balance trainer in combination with a video-game system on balance and gait ability in subacute stroke patients
Hyun Geun Ha, Young Jun Ko, Hwang Jae Lee, Wan Hee Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 2 7-12 (6 pages)
Objective: The purpose of this study was to investigate the effects of a three dimensional balance trainer in combination with a video-game system and visual feedback on balance recovery and gait function in subacute stroke patients. Design: Randomized controlled trial. Methods: Twenty-three subacute stroke patients were assigned to either an experimental (n=12) or a control group (n=11) using a random permuted block design and sealed envelopes. The experimental group received additional... -
The effect of physical training on glutamate transporter expression in an experimental ischemic stroke rat model
Gye-Yeop Kim, Eun-Jung Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 2호 5 87-91 (5 pages)
Objective: The present study was aimed at determining the effect of physical training on glutamate transporter activity in a middle cerebral artery occlusion (MCAO)-induced ischemia injury rat model. Design: Randomized controlled trial. Methods: In this study, we randomly divided them into three groups. Group I included non-occlusion sham controls (n=10), Group II included non-physical training after MCAO (n=10), and Group III included rats that were subjected to physical training after MCAO... -
The effect of focus of attention by electroencephalogramfeedback on balance in young adults
Dong-Yeop Lee, Won-Jae Choi, Seung-Won Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 4 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2012, 제 1권 제 1호 3 13-16 (4 pages)
Objective: Electroencephalogram (EGG)-feedback is a training procedure aimed at altering brain activity, and is used as a treatment for disorders like attention. The purpose of this study was to determine the effects of external focus of attention by EGG-feedback on balance in young adults. Design: Cross-sectional study. Methods: Subject were students in Sahmyook University. Fifty young adults in their twenties and thirties. Subjects were performed both with and without external focus of... -
Researches on learning difficulties in school mathematics in Korea
Jinyoung Nam 경인교육대학교 교육연구원 The Journal of Education 11 Pages
경인교육대학교 교육연구원 The Journal of Education 2019, Vol.2 No.2 4 43-53 (11 pages)
This study reviews researches on learning difficulties in school mathematics conducted in Korea since 2015. It is investigated with a classification of learning disabilities in mathematics (LDM) and low achievement in mathematics (LAM). In total, 23 articles on LDM and 40 articles on LAM are analyzed by school levels, mathematical content and interventions applied. It is found that elementary school students and numbers and operations have been researched more compared to others. A range of... -
스트레스 대처에 어려움을 보이는 유아의 모래상자 놀이 적용 사례연구
장미화(Jang Mi Wha) 한국교원대학교 유아교육연구소 한국유아교육연구 33 Pages
한국교원대학교 유아교육연구소 한국유아교육연구 2013, 제 15권 제 2호 10 237-269 (33 pages)
본 연구는 스트레스 대처에 어려움을 보이는 유아가 모래상자놀이 과정에서 어떻게 자신의 심리적 문제를 표현하고, 표현 양상이 변화되어 가며, 모래상자놀이의 적용 효과는 어떠한지를 분석해 보는데 목적이 있다. 연구 대상 유아는 6년 3개월 된 남아 1명으로 주의산만, 반복적인 일탈행동, 스트레스에 예민한 문제로 의뢰해 온 유아였다. 연구절차는 모래상자놀이 도구 준비, 모래상자놀이 실시, 모래상자놀이 표현, 평가 순으로 진행되었다. 모래상자놀이도구는 Kalff(1966)이 제시한 방법에 따라 2012년 6월 20(수) ~ 10월... -
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo, Hyung-Sik Kim, Kyung-Sun Kang 대한수의학회 Journal of Veterinary Science 12 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 3호 1 319-330 (12 pages)
Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief... -
Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress
Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Woosuk Kim, Hyo Young Jung, Jung Hoon Choi, In Koo Hwang, Je Kyung Seong, Yeo Sung Yo 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 2호 1 127-136 (10 pages)
Aluminum (Al) accumulation increases with aging, and long-term exposure to Al is regarded as a risk factor for Alzheimer’s disease. In this study, we investigated the effects of Al and/or D-galactose on neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons in the hippocampal dentate gyrus. AlCl3 (40 mg/kg/day) was intraperitoneally administered to C57BL/6J mice for 4 weeks. In addition, vehicle (physiological saline) or D-galactose (100 mg/kg) was... -
Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats
Jong Whi Kim, Junghyun Chae , Sung Min Nam, Yo Na Kim, Dae Young Yoo, Jung Hoon Choi, Hyo Young Jung, Wook Song, In Koo Hwang, J 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2015, 제 16권 제 1호 2 11-16 (6 pages)
In the present study, we investigated the effects of treadmill exercise on lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) levels in the hippocampus of Zucker diabetic fatty (ZDF) rats and lean control rats (ZLC) during the onset of diabetes. At 7 weeks of age, ZLC and ZDF rats were either placed on a stationary treadmill or made to run for 1 h/day for 5 consecutive days at 16∼22 m/min for 5 weeks. At 12 weeks of age, the ZDF rats had significantly higher... -
Fast neutron irradiation deteriorates hippocampus-related memory ability in adult mice
Miyoung Yang, Hwanseong Kim, Juhwan Kim, Sung-Ho Kim, Jong-Choon Kim, Chun-Sik Bae, Joong-Sun Kim, Taekyun Shin, Changjong Moon* 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2012, 제 13권 제 1호 1 1-6 (6 pages)
Object recognition memory and contextual fear conditioning task performance in adult C57BL/6 mice exposed to cranial fast neutron irradiation (0.8 Gy) were examined to evaluate hippocampus-related behavioral dysfunction following acute exposure to relatively low doses of fast neutrons. In addition, hippocampal neurogenesis changes in adult murine brain after cranial irradiation were analyzed using the neurogenesis immunohistochemical markers Ki-67 and doublecortin (DCX). In the object... -
Gestalt치료 이론에 의한 예술치료 관점에서의 뮤지컬 활용 연구
한국음악교육학회 음악교육연구 2018, 제 47권 제 3호 2 23-48 (26 pages)
본 연구의 목적은 게슈탈트 치료 이론(GestaltTherapy Theory)에 기초한 예술치료 관점에 입각하여,통합적 문화예술교육의 실현을 위한 뮤지컬 활용을 탐색하는 것이다.이를 위해 게슈탈트 예술치료의 접근방식이 되는 자각,환경접촉,자기접촉,대인관계접촉,종결 과정을 가져와 뮤지컬 교수내용을 이야기치료,노래치료,드라마치료로 재구성하기를 제안한다.이러한 관점은 심동적,정의적 행동양식의 변화뿐만 아니라,심리적 치료가 필요한 청소년 대상 문화예술교육에 영향을 미칠 수 있을 것이라 기대한다.따라서 본 연구는 게슈탈트 치료... -
마음챙김에 기반한 스트레스 완화(MBSR) 프로그램이 남자 고등학생의 주의력과 정서조절양식에 미치는 영향
고종구, 이영순 한국교육치료학회 교육치료연구 21 Pages
한국교육치료학회 교육치료연구 2015, Vol.7 No.1 8 127-147 (21 pages)
본 연구는 마음챙김에 기반한 스트레스 완화(MBSR)프로그램이 남자 고등학생의 주의력과 정서조절 양식에 미치는 영향을 검증하기 위한 목적으로 실시되었다. 전라북도 J시의 인문계 고등학교에 재 학 중인 남자 고등학생을 대상으로 프로그램 참여를 희망하는 32명을 선정하였으며 참여집단과 통 제집단에 각 16명씩 배정하였다. MBSR 프로그램은 4주간 8회기를 실시하였으며, 각 회기는 90-100 분의 시간이 소요되었다. 프로그램을 진행하는 동안 참여집단에서 3명, 통제집단에서 3명이 중도 탈 락하였다. 참여자(참여집단 13명,... -
소아 청소년 우울 장애의 인지적 특성 연구 -K-WISC-III 일반 지능 집단을 중심으로-
이명경, 이현지 한국교육치료학회 교육치료연구 11 Pages
한국교육치료학회 교육치료연구 2011, Vol.3 No.2 5 85-95 (11 pages)
본 연구는 소아 청소년 우울 장애의 인지적 특성을 밝히고자 하였다. 이를 위해 우울 장애로 진단 받은 6에서 16세 사이의 소아 청소년 중 한국 웩슬러 아동 지능 검사 1표준편차 이내에 속하는(전 체 지능 85-115) 소아 청소년 56명의 지능 검사 결과를 4개 요인과 12개 소검사로 나누어 분석하였 다. 그 결과 언어 이해와 지각 조직 요인은 일반 집단과 통계적으로 유의한 차이를 나타내지 않았 으나, 주의 집중 요인은 일반 집단보다 유의하게 높고, 처리 속도 요인은 일반 집단보다 유의하게 낮은 것으로 나타났다. 소검사 중에서는... -
성인 ADHD 성향군의 자기존중감과 자기지각 및 귀인양식
이희경, 장문선 한국교육치료학회 교육치료연구 21 Pages
한국교육치료학회 교육치료연구 2009, Vol.1 No.1 2 11-31 (21 pages)
본 연구는 성인 ADHD 성향집단에서의 자기존중감과 자기지각의 관계와 자기존중감과 귀인양식의 관계를 각각 검토함으로써 자기지각과 귀인양식에 대한 개입이 성인 ADHD 성향집단의 낮은 자기 존중감을 향상시키는데 효과적인 방법이 될 수 있는지 알아보고, 선행연구에서 밝혀진 ADHD 아동 에서의 결과와 비교해 보고자 수행되었다. 연구 결과, ADHD 성향집단과 비성향집단의 자기존중감이 자기지각에 의해 설명될 수 있었다. 그러 나 자기존중감을 예측해 주는 자기지각의 영역에는 두 집단 간 차이가 있었다. 학업역량, 사회적 수 용,... -
Metabotropic glutamate receptor dependent long-term depression in the cortex
SukjaeJoshuaKang, Bong-KiunKaang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.6 1 557-564 (8 pages)
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The hippocampus and the cerebellum have been the most extensively studied regions in mGluR-dependent LTD, and Group 1 mGluR has been reported to be mainly involved in this synaptic LTD at excitatory synapses. However, mGluR-dependent LTD in other brain regions may be involved in the... -
The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia
Kyung-EonLee, Kyung-OkCho, Yun-SikChoi, SeongYunKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.2 7 185-192 (8 pages)
Ampicillin, a β-lactam antibiotic, dose-dependently protects neurons against ischemic brain injury. The present study was performed to investigate the neuroprotective mechanism of ampicillin in a mouse model of transient global forebrain ischemia. Male C57BL/6 mice were anesthetized with halothane and subjected to bilateral common carotid artery occlusion for 40 min. Before transient forebrain ischemia, ampicillin (200 mg/kg, intraperitoneally [i.p.]) or penicillin G (6,000 U/kg or 20,000 U/kg,... -
Role of Cerebrospinal Fluid Biomarkers in Clinical Trials for Alzheimer’s Disease Modifying Therapies
Ju-HeeKang, Na-YoungRyoo, DongWunShin, JohnQTrojanowski, LeslieM.Shaw 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.6 1 447-456 (10 pages)
Until now, a disease-modifying therapy (DMT) that has an ability to slow or arrest Alzheimer’s disease (AD) progression has not been developed, and all clinical trials involving AD patients enrolled by clinical assessment alone also have not been successful. Given the growing consensus that the DMT is likely to require treatment initiation well before full-blown dementia emerges, the early detection of AD will provide opportunities to successfully identify new drugs that slow the course of AD... -
DehydroevodiamineㆍHCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats
HeeJinKim, KiYoungShin, Keun-AChang, SangzinAhn, HeeSoonChoi, Hye-SunKim, Yoo-HunSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2014, Vol.18 No.1 7 55-59 (5 pages)
DehydroevodiamineㆍHCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion... -
Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice
AmarjotKaurGrewal, AmteshwarSinghJaggi, AvtarChRana, NirmalSingh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.6 2 485-492 (8 pages)
The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of grip strength and motor coordination in Swiss albino mice. Administration of carbamazepine (16 mg/kg, i.p.) before global cerebral ischaemia significantly attenuated cerebral infarct size and improved the... -
Chronic Administration of Baicalein Decreases Depression-Like Behavior Induced by Repeated Restraint Stress in Rats
BombiLee, BongjunSur, JinheePark, Sung-HunKim, SunohKwon, MijungYeom, InsopShim, HyejungLee, Dae-hyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.5 3 393-403 (11 pages)
Baicalein (BA), a plant-derived active flavonoid present in the root of Scutellaria baicalensis, has been widely used for the treatment of stress-related neuropsychiatric disorders including depression. Previous studies have demonstrated that repeated restraint stress disrupts the activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression. The behavioral and neurochemical basis of the BA effect on depression remain unclear. The present study used the forced swimming test... -
Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment
Soo-JeongKim, Jun-HoLee, Hwan-SuckChung, Joo-HyunSong, JoohunHa, HyunsuBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 11 331-338 (8 pages)
the scopolamine induced cognitive deficit as evaluated by escape latency in the Morris water maze. In addition, they showed enhanced acetylcholinesterase (AChE)-reactive neurons in the hippocampus, implying increased cholinergic activity in response to AMPK. We also studied the cellular mechanism by which AMPK protects against glutamate- induced cell death in primary cultured rat hippocampal neurons. We further demonstrated that AMPK WT-infected cells increased cell viability and reduced Annexin... -
Synaptic Plasticity in Mouse Models of Autism Spectrum Disorders
LeeyupChung, AlexraL.Bey, Yong-HuiJiang 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.6 1 369-378 (10 pages)
Analysis of synaptic plasticity together with behavioral and molecular studies have become a popular approach to model autism spectrum disorders in order to gain insight into the pathosphysiological mechanisms and to find therapeutic targets. Abnormalities of specific types of synaptic plasticity have been revealed in numerous genetically modified mice that have molecular construct validity to human autism spectrum disorders. Constrained by the feasibility of technique, the common regions... -
Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats
BombiLee, BongjunSur, InsopShim, HyejungLee, Dae-HyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 11 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.2 1 79-89 (11 pages)
of proinflammatory cytokines such as interleukin-1Ղ, tumor necrosis factor-Ձ and cyclooxygenase-2 mRNA in the hippocampus. These results demonstrated that PA and BER had significant neuroprotective effects against neuronal impairment and memory dysfunction caused by scopolamine in rats. These results suggest that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses. -
Stem Cells in Drug Screening for Neurodegenerative Disease
Hyun-JungKim, ChangYunJin 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 9 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.1 1 1-9 (9 pages)
Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective drugs that increase neurogenesis. Recent technologies for human embryonic stem cells (ESCs) or induced... -
The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats
Hyun-JungPark, HyunSooShim, KyungSooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2011, Vol.15 No.6 3 333-338 (6 pages)
we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the rats were administered BG (100 or 400 mgkg−1, p.o.) daily for 2 weeks, followed by training and performance of the Morris water maze test. The rats with ischemic... -
Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia
RohitKumar, AmteshwarSinghJaggi, NirmalSingh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 15 345-352 (8 pages)
The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, 10Ռl, 1st and 3rd day) in separate groups of animals. Morris water- maze test was employed to assess learning and memory. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative... -
The Effects of Glutamate NMDA Receptor Antagonist MK-801 on Gastrointestinal Motility after Middle Cerebral Artery Occlusion in Rats
NasirHussinAmeer, JaeHeeLee, MyoungAeChoi, Guang-ShiJin, MinSunKim, ByungRimPark 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.3 6 151-156 (6 pages)
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The Effects of Astragalus Membranaceus on Repeated Restraint Stress-induced Biochemical and Behavioral Responses
Hyun-JungPark, HyunYoungKim, Kun-HoYoon, KyungSooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 5 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.4 8 315-319 (5 pages)
Astragalus Membranaceus (AM) is a useful Korean herb that has been clinically prescribed for stress-related illness. The objective of the present study was to examine the anti-stress effects of AM on repeated stress-induced alterations of anxiety, learning and memory in rats. Restraint stress was administered for 14 days (2h/day) and AM (400mg/kg) given by oral administration, in the AM group, for the same period. Starting on the eighth day, the rats were tested for spatial memory on the Morris... -
The Effects of Puerariae Flos on Stress-induced Deficits of Learning and Memory in Ovariectomized Female Rats
Hyun-JungPark, Seung-MooHan, WonJuYoon, Kyung-SooKim, InsopShim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 3 85-90 (6 pages)
Puerariae flos (PF) is a traditional oriental medicinal plant and has clinically been prescribed for a long time. The purpose of the present study was to examine the effect of PF on repeated stress-induced alterations of learning and memory on a Morris water maze (MWM) test in ovariectomized (OVX) female rats. The changes in the reactivity of the cholinergic system were assessed by measuring the immunoreactive neurons of choline acetyltransferase (ChAT) in the hippocampus after behavioral... -
Maternal Social Separation of Adolescent Rats Induces Hyperactivity and Anxiolytic Behavior
HyongRyolKwak, JaeWonLee, Kwang-JunKwon, ChangDonKang, IlYoungCheong, WanjooChun, Sung-SooKim, HeeJaeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2009, Vol.13 No.2 2 79-84 (6 pages)
Exposure to early stressful adverse life events such as maternal and social separation plays an essential role in the development of the nervous system. Adolescent Sprague-Dawley rats that were separated on postnatal day 14 from their dam and litters (maternal social separation, MSS) showed hyperactivity and anxiolytic behavior in the open field test, elevated plus-maze test, and forced-swim test. Biologically, the number of astrocytes was significantly increased in the prefrontal cortex of MSS...
