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The effects computerized cognitive rehabilitation on cognitive function, depression, rehabilitative motivation in older adults with mild cognitive impairment : A pilot study
Moon Jong-Hoon 고령자치매작업치료학회 고령자·치매작업치료학회지 8 Pages
고령자치매작업치료학회 고령자·치매작업치료학회지 2019, 제 13권 제 2호 4 25-32 (8 pages)
: This pilot study aims to investigate the effects of computerized cognitive rehabilitation on cognitive function, depression, and rehabilitative motivation in older adults with mild cognitive impairment (MCI). Methods : This pilot study follows a pre-post design and 15 older adults with MCI participated. The intervention comprised of 30-minute sessions 4 to 5 times a week for 4 weeks. The Lowenstein Occupational Therapy Cognitive Assessment-G (LOTCA-G), the short form Geriatric Depression Scale... -
Effects of the Occupational Therapy Using the Music-Based Cognitive Stimulation Digital Device Program on Elderly’s Cognitive Function, Depression and Hand Function
Lee Bo-Min, Sung Yoon-Jeong, Lee Jung-Hwa, Han Eun-Young, Yang Yeong-Ae 대한고령친화산업학회 대한고령친화산업학회지 11 Pages
대한고령친화산업학회 대한고령친화산업학회지 2021, 제 13권 제 1호 1 1-11 (11 pages)
the positive improvement on the cognitive function. And, the program improved depression and hand function significantly. Conclusion : The occupational therapy using the music-based cognitive stimulation digital device program have positive influence on the improvement of cognitive function, depression and hand function of elderly aged 65 or older. Furthermore, it suggests that these occupational therapies can be used as one approach to programs to improve risk factors for preventing dementia. -
Effects of Long- and Short-term Consumption of Energy Drinks on Anxiety-like, Depression-like, and Cognitive Behavior in Adolescent Rats
Lee Joo Hee, Lee Jong Hyeon, Choi You Jeong, Kim Youn Jung 한국기초간호학회 Journal of Korean Biological Nursing Science 8 Pages
한국기초간호학회 Journal of Korean Biological Nursing Science 2020, Volume 22, No 2 5 111-118 (8 pages)
for one day, and the control group applied the same amount of normal saline. Later, an open-field test, a forced swim test, novel object recognition test, and an 8-arm radial maze test was conducted to assess the rats’ anxiety, depression, and cognitive function. Results: There were different effects in the long- and short-term groups of energy drink administration. In the LT group, anxiety- and depressive-like behavior increased because of increased movement in the side corner and decrease of... -
Mediating Effects of Cognitive Effort and Depression on Intelligence, Memory, and Executive Functions in Individuals with Mild Traumatic Brain Injury
KyoungSae Na, HanYong Jung, Soyoung Irene Lee, ShinGyeom Kim 대한신경정신의학회 Psychiatry Investigation 7 Pages
대한신경정신의학회 Psychiatry Investigation 2004, 제 11권 제 2호 2 112-118 (7 pages)
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Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain
Ataie. Amin, Sabetkasaei. Masoumeh, Haghparast. Abbas, Moghaddam. Akbar Hajizadeh, Ataee. Ramin, Moghaddam. Shiva Nasiraei 한국식품영양과학회 Journal of medicinal food 6 Pages
한국식품영양과학회 Journal of medicinal food 2010, Vol.13 No.4 821-826 (6 pages)
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Effects of Teaching Strategies according to Piagetian Cognitive Developmental Stages
김현재, 서자경, Kim. Hyun-Jae, Suh. Ja-Kyoung 한국과학교육학회 한국과학교육학회지 14 Pages
한국과학교육학회 한국과학교육학회지 1988, Vol.8 No.1 81-94 (14 pages)
본 연구의 목적은 Piaget의 인지발달단계(전조작 구체적 조작 단계)에 따른 자연과 개념획득에 효과적인 교수전략을 탐색하기 위한 연구로서, 첫째는 문헌연구를 통해서, Piaget의 인지이론을 기초로한 교육론과 개념학습을 위한 교수전략을 연구함으로써 전조작 단계의 어린이, 구체적 조작단계의 어린이에게는 연역적 교수전략보다 귀납적 교수전략이 더 효과적이며, 구체적 조작단계의 어린이에게는 초보적인 논리능력이 발달하므로 연역적 교수전략도 가능하며, 이 2가지의 인지단계가 복합돼 있는 국민학교 2학년 집단에게는 귀납적... -
A Double-Blind, Sham-Controlled, Pilot Study to Assess the Effects of the Concomitant Use of Transcranial Direct Current Stimulation with the Computer Assisted Cognitive Rehabilitation to the Prefrontal Cortex on Cognitive Functions in Patients with Stroke
Park. See-Hyun, Koh. Eun-Jeong, Choi. Ha-Young, Ko. Myoung-Hwan 대한신경외과학회 Journal of Korean neurosurgical society 5 Pages
대한신경외과학회 Journal of Korean neurosurgical society 2013, Vol.54 No.6 484-488 (5 pages)
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Effects of Korean Red Ginseng on Cognitive and Motor Function: A Double-blind, Randomized, Placebo-controlled Trial
Yeo. Hye-Bin, Yoon. Ho-Kyoung, Lee. Heon-Jeong, Kang. Seung-Gul, Jung. Ki-Young, Kim. Leen 고려인삼학회 Journal of ginseng research 8 Pages
고려인삼학회 Journal of ginseng research 2012, Vol.36 No.2 190-197 (8 pages)
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Effects of Group Cognitive-Behavioral Therapy in Young Patients in the Early Stage of Psychosis
SungWan Kim, JiEun Jang, JuYeon Lee, GaYoung Lee, HyeYoung Yu, Cheol Park, HeeJu Kang, JaeMin Kim, JinSang Yoon 대한신경정신의학회 Psychiatry Investigation 9 Pages
대한신경정신의학회 Psychiatry Investigation 2017, 제 14권 제 5호 12 609-617 (9 pages)
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The effects of an additional weight aquatic exercise program on balance and lower extremity strength in persons with stroke
Jae-ho Park, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2018, 제 7권 제 1호 2 6-12 (7 pages)
Objective: The purpose of this study was to investigate the effects of an additional weight aquatic exercise program on the balance and lower extremity strength on aquatic environment in persons with stroke. Design: Randomized controlled trial. Methods: All subjects were randomly divided into three groups where thirteen subjects were in the additional weight aquatic exercise group, twelve subjects in the aquatic exercise group, and fifteen subjects in the control group. Subjects received a... -
Effects of visual restriction and unstable base dual-task training on balance and concentration ability in persons with stroke
Dong-Hoon Kim, Kyung-Hun Kim, Suk-Min Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 4호 5 193-197 (5 pages)
In the present study, the effects of visual restriction and unstable base dual-task training (VUDT), stable base dual-task training (SDT), and on stroke patients’ balance and concentration abilities were examined. Design: Two-group pretest-posttest design. Methods: Dual-task training was conducted for thirty persons with chronic stroke who were hospitalized or receiving physical therapy and were randomly assigned to either the VUDT group (n=15) or the SDT group (n=15). The subjects were divided... -
Effects of relaxation approach with self-exercise on head posture, static postural stability, and headache in persons with tension-type headache
Sang-Yong Park, Su-jin Hwang 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 4호 3 178-184 (7 pages)
Objective: Tension-type headache is caused by hormones, foods, irritants, stress, obesity, fatigue, and neck and head trigger points-prolonged abnormal posture. The purpose of this study was to evaluate the effects of relaxation approach on head posture, static postural stability, and headache in persons with tension-type headache. Design: Randomized controlled trial. Methods: Thirty-five persons with tension-type headache participated in this study. This study was a pretest-posttest with a... -
Effects of ball kicking dual task training on gait performance and balance in individuals with chronic hemiparetic stroke
Min-seong Kim, Jae-hun Shim, Kyung-hoon Yu, Ji-won Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 8 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 4호 2 170-177 (8 pages)
cognitive task with general treadmill gait training (TGT) on gait speed, gait endurance, functional gait, balance and balance confidence in patients with chronic hemiparetic stroke. Design: Randomized controlled trial. Methods: Fourteen stroke patients who volunteered to participate in this study were randomly divided into two groups with seven patients in each group: ball kicking dual task training (DTT) group and TGT group. The DTT group received ball kicking DTT with cognitive tasks consisted... -
The effects of providing visual feedback and auditory stimulation using a robotic device on balance and gait abilities in persons with stroke
Jae Ho Park, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 3호 3 125-131 (7 pages)
investigate the effects of providing visual feedback and auditory stimulation using a robotic device on balance and gait abilities in stroke patients. Design: Randomized controlled pilot trial. Methods: Fifteen subjects were randomly divided into three groups where five subjects were in the visual feedback robotic device assist gait training (VRGT) group, five subjects in the auditory stimulation robotic device assist gait training (ARGT) group, and five subjects in the control group. Subjects... -
Effects of sit-to-stand imagery group training on balance performance in individuals with chronic hemiparetic stroke
Jeong-won Lee, Su-jin Hwang, Sin-ae Ahn 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2016, 제 5권 제 2호 2 63-69 (7 pages)
Objective: To evaluate the effects of sit-to-stand (STS) imagery group training (IGT) on STS movement and balance performance for chronic hemiparetic stroke. Design: Randomized controlled trial. Methods: A total of 30 people with chronic hemiparetic stroke (15 for STS-IGT group and 15 for control) were recruited in this study. The STS-IGT group participated in a videotape-based STS-IGT for 30 minutes a day, five days a week for six weeks, while the control group watched a documentary on... -
Effects of balance imagery of semi-tandem stance on a flat floor and balance beam for postural control
Jeong-Weon Lee, Su-jin Hwang 물리치료재활과학회 Physical Therapy Rehabilitation Science 7 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2015, 제 4권 제 2호 5 87-93 (7 pages)
and functional activities, it is also necessary to imagine an appropriate and effective movement representation used to plan and execute the functional activities. The purpose of this study was to evaluate the effects of balance imagery of semi-tandem stance on a flat floor and balance beam on balance abilities for elderly and young adults. Design: Cross-sectional study. Methods: Fifteen elderly and thirty-four young adults were enrolled in this study. In order to determine whether there is a... -
Effects of body weight-supported treadmill training combined with ball-kicking on balance and gait of subacute stroke patients
Ju-chul Cho, Eun-sang Lee, Seung-won Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2015, 제 4권 제 2호 3 73-78 (6 pages)
Objective: This study focused on subacute stroke patients who were asked to kick a ball while walking on a treadmill. The aim of the study was to determine the effect of a body weight-supported treadmill training (BWSTT) combined with ball-kicking on muscle strength, balance, and gait. Design: Single blind, randomized controlled trial. Methods: Twenty stroke patients who volunteered to participate in this study were randomly assigned to either the BWSTT combined with ball-kicking (BWSTT-BK; 10... -
Effects of mobile texting and gaming on gait with obstructions under different illumination levels
Jae-yun Cha, Hyun-jin Kim, Jae-myoung Park, Chang-ho Song 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2015, 제 4권 제 1호 6 32-37 (6 pages)
Objective: This study was conducted to test the effects of mobile texting and gaming on gait with obstructions under different illumination levels. Design: Cross-sectional study. Methods: Twelve healthy adults aged 20 to 36 years (mean 23.5 years) were tested under six different conditions. All participants used touchscreen smartphones. Testing conditions included: 1) Walking with an obstruction under a bright illumination level; 2) walking with an obstruction with a low level of illumination;... -
The effects of motor imagery training on brain waves in persons post-stroke
Hyang-Woon Yoon, Seong-Sik Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 10 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2015, 제 4권 제 1호 1 1-10 (10 pages)
Objective: The purpose of this study was to investigate whether motor imagery training (MIT) combined with physical training could have a positive influence on brain waves in stroke patients. Design: Randomized controlled trial. Methods: Twenty-four survivors of a first-time stroke participated in the study. All patients were randomly assigned to one of two groups: (1) MIT group (n=12) and (2) control group (n=12). The MIT group participated in a total of 30 minutes of motor imagery (MI) on each... -
The grading of cognitive state comparisons with different distances across three conditions in stroke survivors
Yu-mi Kim, Yu-hyung Park 물리치료재활과학회 Physical Therapy Rehabilitation Science 8 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 2호 9 134-141 (8 pages)
conditions in stroke survivors with the grading of cognitive state. Design: Cross-sectional study. Methods: Twelve stroke patients who agreed to active participation were included. Participants were allotted to normal cognitive (CN) group (n=7) and cognitive impairment (CI) group (n=5) and then walked on a self-paced walkway at three conditions on the Time Up and Go (TUG) test and the 6 minute walk test (6MWT): 1) walking with your comfortable speed, 2) walking while carrying a tray with glasse... -
The immediate effects of patellar taping on balance and gait ability in individuals with chronic stroke
Jin Shin, Mee-Hyang Mun, Yi-jung Chung 물리치료재활과학회 Physical Therapy Rehabilitation Science 9 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 2호 8 125-133 (9 pages)
Objective: The aim of this study is to investigate the effect of patellar taping on balance and gait abilities in chronic stroke patients. Design: Randomized placebo-controlled trial. Methods: Thirty chronic stroke patients who have been diagnosed at least six months or before were recruited from R hospital. These study subjects were randomized to the experimental group (n=15) or placebo group (n=15). In the experimental group, patellar taping was applied while for the placebo group, placebo... -
Effects of 3-dimensional balance trainer in combination with a video-game system on balance and gait ability in subacute stroke patients
Hyun Geun Ha, Young Jun Ko, Hwang Jae Lee, Wan Hee Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2014, 제 3권 제 1호 2 7-12 (6 pages)
Objective: The purpose of this study was to investigate the effects of a three dimensional balance trainer in combination with a video-game system and visual feedback on balance recovery and gait function in subacute stroke patients. Design: Randomized controlled trial. Methods: Twenty-three subacute stroke patients were assigned to either an experimental (n=12) or a control group (n=11) using a random permuted block design and sealed envelopes. The experimental group received additional... -
The effects of treadmill training on dynamic balance and gait function in stroke patients
Eun Jung Chung, Byoung-hee Lee 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 1호 7 39-43 (5 pages)
Objective: The objective of this study is to investigate the effect of treadmill gait trainig on dynamic balance and gait functions in stroke patients. Design: Randomized, double-blind, controlled pilot study. Methods: Four subjects following first stroke participated in this study. They were divided randomly into the treadmill gait trainig group (TM group) (n=2) and the control group (n=2). Subjects in both groups received general training five times per week. Subjects in the TM group practiced... -
The effects of virtual reality-based physical therapy in stroke patients
Cha-ryong Kim, Won-Kyu Min 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 1호 2 7-11 (5 pages)
Objective: Final goal of nerve advancement therapy is to provide maximum ability to function independently in life to patients. This paper appraises and describes basic concepts of the virtual reality (VR) based exercise program to improve functional movement for neurologically impaired patients. Design: Review article. Methods: Stroke patients from the physical therapy department while wearing comfortable clothing receive therapy and also VR based motion therapy administered by the therapist in... -
The effects of EMG-triggered functional electrical stimulation on upper extremity function in stroke patients
Young Kim 물리치료재활과학회 Physical Therapy Rehabilitation Science 6 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2013, 제 2권 제 1호 1 1-6 (6 pages)
explore the latest intervention trends and effects of EMG-triggered functional electrical stimulation on the upper extremity functions in stroke patients. Design: Systematic review on clinical trials. Methods: A systematic literature search was performed to identify clinical trials evaluating the effects of EMG-triggered functional electrical stimulation (EMG-FES) and task-oriented EMG-triggered FES on the hand functions in stroke patients. Literature review was conducted with the following key... -
The effects of dual-task training on ambulatory abilities of stroke patients
Gyu Chang Lee, Won Jae Choi 물리치료재활과학회 Physical Therapy Rehabilitation Science 5 Pages
물리치료재활과학회 Physical Therapy Rehabilitation Science 2012, 제 1권 제 1호 1 1-5 (5 pages)
Objective: Dual-task walking deficits impact functional daily life, which often requires walking while performing simultaneous tasks such as talking, thinking or carrying an object. This study is to find out the latest trend of dual-task training’s influence on ambulatory abilities of a stroke patient. Design: Systematic review of randomized controlled trials. Methods: This literature review was conducted in Pubmed and Sciencedirect with the follwing key words:stroke, cerebro-vascular accident,... -
Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)
Tomohiro Kondo, Suguru Yoshida, Hiroaki Nagai, Ai Takeshita, Masaki Mino, Hiroshi Morioka, Takayuki Nakajima, Ken Takeshi Kusakabe, Tosh 대한수의학회 Journal of Veterinary Science 7 Pages
대한수의학회 Journal of Veterinary Science 2018, 제 19권 제 4호 5 505-511 (7 pages)
At 5 and 10 days after BCCAO, extensive neuronal cell death was observed in the hippocampal CA1 region. Cognitive performance was evaluated by using the radial maze and passive avoidance tests. In the radial maze test, which examines win-stay performance, the number of errors was significantly higher in ischemic gerbils than in sham-operated gerbils on days 1 and 2 post-operation. In the passive avoidance test, the latency and freezing times were significantly shorter in ischemic gerbils than in... -
Effects of aluminum on the reduction of neural stem cells, proliferating cells, and differentiating neuroblasts in the dentate gyrus of D-galactose-treated mice via increasing oxidative stress
Sung Min Nam, Jong Whi Kim, Dae Young Yoo, Woosuk Kim, Hyo Young Jung, Jung Hoon Choi, In Koo Hwang, Je Kyung Seong, Yeo Sung Yo 대한수의학회 Journal of Veterinary Science 10 Pages
대한수의학회 Journal of Veterinary Science 2016, 제 17권 제 2호 1 127-136 (10 pages)
we investigated the effects of Al and/or D-galactose on neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons in the hippocampal dentate gyrus. AlCl3 (40 mg/kg/day) was intraperitoneally administered to C57BL/6J mice for 4 weeks. In addition, vehicle (physiological saline) or D-galactose (100 mg/kg) was subcutaneously injected to these mice immediately after AlCl3 treatment. Neural stem cells, proliferating cells, differentiating neuroblasts, and mature neurons... -
Evaluation of the estrogenic effects of dietary perinatal Trifolium pratense
Emrah Yatkin, Suzan Daglioglu 대한수의학회 Journal of Veterinary Science 6 Pages
대한수의학회 Journal of Veterinary Science 2011, 제 12권 제 2호 3 121-126 (6 pages)
to investigate the potential estrogenic effects of perinatal dietary phytoestrogens on the rat uterus. Pregnant rats were divided to three groups provided the following diets: (1) rat chow, (2) rat chow with 7.5% Trifolium (T.) pratense, or (3) rat chow supplemented with 17β-estradiol (0.5 mg/kg). The dams in each group were kept on the same diet during pregnancy and lactation. Female offspring were euthanized on day 21 at which time body and organ weights were recorded and tissue samples were... -
Application and Effects of Music Appreciation Model for Emotional Development
Su-Young Bae 한국음악교육학회 음악교육연구 20 Pages
한국음악교육학회 음악교육연구 2021, 제 50권 제 2호 4 69-88 (20 pages)
find out the effects of applying the Music Appreciation Model for Emotional Development (MAMED). A qualitative case study approach was employed and data were collected through two self-reported emotion charts, two music appreciation reports, and one final reflection paper from each student. The results are first, 83.78% of the students answered that their emotional experiences were different in emotivist and cognitivist music listening conditions. Second, the students were able to improve their... -
A Study on the Effects of Flipped Learning on Inferential English Reading Skills of Korean High School Students
Boram Lee, Dong Ju Lee 한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 13 Pages
한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning 2018, 제 8권 제 4호 4 179-191 (13 pages)
a positive influence not only on the cognitive domain such as general English reading abilities, but also on the affective domain of the students. Flipped learning has been vaguely understood and diversely interpreted among the practitioners in the educational fields even though it is one of the most adequate pedagogical approaches in teaching. In order to maximize learning through the flipped learning approach, classrooms equipped with multimedia, which gives students an easy access seem ideal. -
Effects of tianeptine on symptoms of fibromyalgia via BDNF signaling in a fibromyalgia animal model
HwayoungLee, JiyunIm, HansolWon, WooyoungNam, YoungOckKim, SangWonLee, SanghyunLee, Ik-HyunCho, Hyung-KiKim, Jun-TackKwon, Hak-JaeKim 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.4 1 361-370 (10 pages)
Previous reports have suggested that physical and psychological stresses may trigger fibromyalgia (FM). Stress is an important risk factor in the development of depression and memory impairments. Antidepressants have been used to prevent stress-induced abnormal pain sensation. Among various antidepressants, tianeptine has been reported to be able to prevent neurodegeneration due to chronic stress and reverse decreases in hippocampal volume. To assess the possible effect of tianeptine on FM... -
Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models
KiYoungShin, KaYoungKim, Yoo-HunSuh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2017, Vol.21 No.1 7 55-64 (10 pages)
which is a progressive neurodegenerative disorder, prominently features a memory and learning impairment that is related to changes in acetylcholine and abnormal β-amyloid (Aβ) deposition in the brain. In the present study, we investigated the effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water... -
Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway
EunkyungLee, So-YoungChoi, Jae-HoYang, YounJuLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 9 399-406 (8 pages)
pharmacological effects including neuroprotection. In this study, the effects of imperatorin on PFHxS-induced neuronal apoptosis and the underlying mechanisms are examined using cerebellar granule cells (CGC). CGC were isolated from seven-day old rats and were grown in culture for seven days. Caspase-3 activity and TUNEL staining were used to determine neuronal apoptosis. PFHxS-induced apoptosis of CGC was significantly reduced by imperatorin and PD98059, an ERK pathway inhibitor. PFHxS induced... -
Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder
BombiLee, BongjunSur, MijungYeom, InsopShim, HyejungLee, Dae-HyunHahm 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 10 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2016, Vol.20 No.4 5 357-366 (10 pages)
Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p.,... -
Neuroprotective Effects of AMP-Activated Protein Kinase on Scopolamine Induced Memory Impairment
Soo-JeongKim, Jun-HoLee, Hwan-SuckChung, Joo-HyunSong, JoohunHa, HyunsuBae 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2013, Vol.17 No.4 11 331-338 (8 pages)
rat hippocampal neurons. We further demonstrated that AMPK WT-infected cells increased cell viability and reduced Annexin V positive hippocampal neurons. Western blot analysis indicated that AMPK WT-infected cells reduced the expression of Bax and had no effects on Bcl-2, which resulted in a decreased Bax/Bcl-2 ratio. These data suggest that AMPK is a useful cognitive impairment treatment target, and that its beneficial effects are mediated via the protective capacity of hippocampal neurons. -
Effects of Treadmill Exercise on the Recovery of Dopaminergic Neuron Loss and Muscle Atrophy in the 6-OHDA Lesioned Parkinson's Disease Rat Model
Myoung-AeChoe, Byung-SooKoo, GyeongJuAn, SongheeJeon 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.5 3 305-312 (8 pages)
This study was to determine the effect of exercise on the recovery of dopaminergic neuron loss and muscle atrophy in 6-OHDA-induced hemi Parkinson's disease model. Exercise was loaded twice per day for 30 minutes each time, at 5 days after 6-OHDA lesioning and continued for 16 days using a treadmill. Exercise significantly increased the number of tyrosine hydroxylase positive neuron in the lesioned substantia nigra and the expression level of tyrosine hydroxylase in the striatum compared with... -
Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats
Ji-YoungJung, MootaekRoh, Kyung-KyunKo, Hwan-SooJang, , Seong-RyongLee, Jeoung-HeeHa, Il-SungJang, , Ho-WonLee, Maan-GeeLee 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 6 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2012, Vol.16 No.4 2 231-236 (6 pages)
We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake... -
Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia
RohitKumar, AmteshwarSinghJaggi, NirmalSingh 대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 8 Pages
대한생리학회-대한약리학회 The Korean Journal of Physiology & Pharmacology 2010, Vol.14 No.5 15 345-352 (8 pages)
The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ, 3 mg/kg, 10Ռl, 1st and 3rd day) in separate groups of animals. Morris water- maze test was employed to assess learning and memory. The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative...
