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61.

Desipramine 장기투여가 백서 대뇌피질의 Adenylate Cyclase 의 활성도와 GABAb 및 Noradrenaline 수용체후 구조의 Coupling system 에 미치는 영향

金唤, 薫, , 橋本桓, 栗山欣彌 대한신경정신의학회 신경정신의학 18 Pages

대한신경정신의학회 신경정신의학 1994, 제 33권 제 3호 14 648-665 (18 pages)

金唤, 薫, , 橋本桓, 栗山欣彌 저
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- 4,700원
62.

흰쥐 지방세포에 있어서 Amiloride의 A1 Adenosine Receptor- Adenylyl Cyclase System에 대한 작용

박경선(Kyung Sun Park), 이명순(Myung Soon Lee), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 8 Pages

대한약리학회 대한약리학잡지 1993, 제 29권 제 2호 10 245-252 (8 pages)

박경선(Kyung Sun Park), 이명순(Myung Soon Lee), 김경환(Kyung Hwan Kim) 저
...
- 3,000원
Amiloride는 Na+ channels를 선택적으로 억제하는 potassium sparing diuretic이다. 본 연구에서는 amiloride와 아데노신 수용체의 상호작용을 밝히고자, 흰쥐에서 얻은 crude adipocytic membrane fractions의 adenylyl cyclase activity를 여러 조건하에서 측정하였다. 우선 GTP가 isoproterenol-stimulated adenylyl cyclase activity에 미치는 영향을 조사함으로서 Gi protein (inhibitory guanine nucleotide binding protein)의 기능을 알아보았다. 그 결과 amiloride는 높은 GTP 농도에서 isoproterenol-stimulated adenylyl...
63.

Streptozotocin으로 당뇨병을 유발시킨 쥐의 지방세포에 나타나는 A1, Adenosine Receptor-Adenylyl Cyclase System의 변화

박경선(Kyung Sun Park), 이명순(Myung Soon Lee), 김경환(Kyung Hwan Kim) 대한약리학회 대한약리학잡지 10 Pages

대한약리학회 대한약리학잡지 1993, 제 29권 제 1호 10 97-106 (10 pages)

박경선(Kyung Sun Park), 이명순(Myung Soon Lee), 김경환(Kyung Hwan Kim) 저
...
- 3,000원
흰쥐의 지방세포에 존재하는 아데노신 수용체는 A1, subclass로 알려져 있다. 따라서 효현제 (Agonist)에 의해 자극되면 adenylyl cyclase가 억제되고 결과적으로 지방분해가 억제된다. 본 연구에서는 당뇨병으로 인하여 생기는 쥐의 지방세포의 A1. 아데노신 수용체-adenylyl cyclase 시스템의 변화를 규명하고자 하였다. 흰쥐에 streptozotocin을 투여하여 당뇨병을 유발시킨 후 1주일이 되는 날, 굶기지 않은 쥐에 서 collagenase를 사용하여 지방세포를 분리하였다. 분리한 지방세포에 1 unit/ml adenosine deaminase와 1μM...
64.

Cell-free Myeloperoxidase/H2O3/Chloride System에서 Singlet Oxygen이 관여한다는 실험적 증거

정명희(Myung-Hee Chung), 김용식(Yong-Sik Kim) 대한약리학회 대한약리학잡지 12 Pages

대한약리학회 대한약리학잡지 1984, 제 20권 제 1호 1 1-12 (12 pages)

정명희(Myung-Hee Chung), 김용식(Yong-Sik Kim) 저
...
- 4,100원
및 methional에서의 ethylene 생성을 관찰하여 cell-free MPO/H2O2/Cl- system에서 관여하는 oxygen metabolites가 무엇인지를 규명하기 위하여 본 실험을 수행하였다. 1) NADH는 MPO/H2O2/Cl-에 의하여 산화됨을 확인하였다. 즉 MPO, H2O2 및 Cl-가 존재하는 medium에서 NADH의 산화는 azide와 catalase에 의하여, 그리고 medium에서 Cl-를 제거하였을 때 완전히 제거되었다. 2) 이와같은 MPO/H2O2/Cl-에 의한 NADH산화는 1O2 제거물질인 1,4-diazabicyclo(2,2,2) octane(DABCO)에 의하여 완전히 억제 되었으나 OH⋅의 제거물질인...
65.

Effect of Cadmium on Organic Acid Transport System in Renal Basolateral Membrane

Kim, Ghi-Chan, Kim, Kyoung-Ryong, Kim, Jee-Yeun, Park, Yang-Saeng 대한생리학회 대한생리학회지 10 Pages

대한생리학회 대한생리학회지 1996, 제 30권 제 2호 10 279-288 (10 pages)

Kim, Ghi-Chan, Kim, Kyoung-Ryong, Kim, Jee-Yeun, Park, Yang-Saeng 저
...
- 3,000원
Chronic exposure to cadmium impairs various renal tubular functions, including organic acid (anion) secretion. To investigate the mechanism of cadmium-induced alterations in the organic anion transport system, kinetics of p-aminohippurate (PAH) uptake was studied in renal cortical basolateral membrane vesicles (BLMV) isolated from cadmium-intoxicated rats (adult male Sprague-Dawley). Cadmium intoxication was induced by subcutaneous injections of CdCl2 (2 mg Cd/kg per day) for 3 weeks. The renal...
66.

Short- and Long-term Effects of Potassium on Renin-Aldosterone System in Hypertensive Rats Fed with Different Amounts of Sodium

Kim, Sook-Young, Yang, Eun-Kyung, Park, Jae-Sik, Lee, Won-Jung, Kim, Suhn-Hee 대한생리학회 대한생리학회지 12 Pages

대한생리학회 대한생리학회지 1991, 제 25권 제 1호 7 69-80 (12 pages)

Kim, Sook-Young, Yang, Eun-Kyung, Park, Jae-Sik, Lee, Won-Jung, Kim, Suhn-Hee 저
...
- 4,100원
To evaluate the acute and chronic effects of potassium on aldosterone response to different amounts of sodium intake, two series of experiments were conducted. In the first series of experiments, when the plasma K level was increased acutely by KCI infusion (20 μg/kg/min for 20 min), plasma aldosterone concentration increased in both low Na and high Na groups. However, the aldosterone response to K infusion was significantly greater in the low Na than in the high Na groups. In the second series...
67.

Study on the User Selection System and the Change of Composition of Social Service Providers in Japan - Centering on the Analyses of Care Services for the Elderly andWelfare Services for Persons with Disabilities

Chang-Wan HAN, Toshihiro Fukushima, Masafumi Ide, Etsuo Horikawa 한국사회서비스학회 사회서비스연구 29 Pages

한국사회서비스학회 사회서비스연구 2011, 제 2권 제 2호 5 141-169 (29 pages)

Chang-Wan HAN, Toshihiro Fukushima, Masafumi Ide, Etsuo Horikawa 저
...
- 5,800원
This study aimed to explore the history of marketization and decentralization of welfare in Japan, to examine the discussions about the introduction of user selection system that has been represented as themotto of ‘FromMeasures to Contract’ and the principle of self-responsibility and to analyze the change of social service providers for the long-termcare services for the elderly andwelfare services for persons with disabilities. The biggest changes that were caused by implementing...
68.

Inhibitory Activity of Sedum middendorffianum-Derived 4-Hydroxybenzoic Acid and Vanillic Acid on the Type III Secretion System of Pseudomonas syringae pv. tomato DC3000

Ji Eun Kang, Byeong Jun Jeon, Min Young Park, Beom Seok Kim 한국식물병리학회 The Plant Pathology Journal 10 Pages

한국식물병리학회 The Plant Pathology Journal 2020, 36권 6호 8 608-617 (10 pages)

Ji Eun Kang, Byeong Jun Jeon, Min Young Park, Beom Seok Kim 저
...
- 3,000원
The type III secretion system (T3SS) is a key virulence determinant in the infection process of Pseudomonas syringae pv. tomato DC3000 (Pst DC3000). Pathogen constructs a type III apparatus to translocate effector proteins into host cells, which have various roles in pathogenesis. 4-Hydroxybenozic acid and vanillic acid were identified from root extract of Sedum middendorffianum to have inhibitory effect on promoter activity of hrpA gene encoding the structural protein of the T3SS apparatus. The...
69.

Characterization of Type VI Secretion System in Xanthomonas oryzae pv. oryzae and Its Role in Virulence to Rice

Yeounju Choi, Namgyu Kim, Mohamed Mannaa, Hongsup Kim, Jungwook Park, Hyejung Jung, Gil Han, Hyun-Hee Lee, Young-Su Seo 한국식물병리학회 The Plant Pathology Journal 8 Pages

한국식물병리학회 The Plant Pathology Journal 2020, 36권 3호 9 289-296 (8 pages)

Yeounju Choi, Namgyu Kim, Mohamed Mannaa, Hongsup Kim, Jungwook Park, Hyejung Jung, Gil Han, Hyun-Hee Lee, Young-Su Seo 저
...
- 3,000원
Type VI secretion system (T6SS) is a contact-dependent secretion system, employed by most gram-negative bacteria for translocating effector proteins to target cells. The present study was conducted to investigate T6SS in Xanthomonas oryzae pv. oryzae (Xoo), which causes bacterial blight in rice, and to unveil its functions. Two T6SS clusters were found in the genome of Xoo PXO99A. The deletion mutants, Δhcp1, Δhcp2, and Δhcp12, targeting the hcp gene in each cluster, and a double-deletion...
70.

Genome-Wide Analysis of Type VI System Clusters and Effectors in Burkholderia Species

한국식물병리학회 The Plant Pathology Journal 12 Pages

한국식물병리학회 The Plant Pathology Journal 2018, 34권 1호 2 11-22 (12 pages)

저
...
- 4,100원
secretion system (T6SS) has been discovered in a variety of gram-negative bacteria as a versatile weapon to stimulate the killing of eukaryotic cells or prokaryotic competitors. Type VI secretion effectors (T6SEs) are well known as key virulence factors for important pathogenic bacteria. In many Burkholderia species, T6SS has evolved as the most complicated secretion pathway with distinguished types to translocate diverse T6SEs, suggesting their essential roles in this genus. Here we attempted...

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