3-Oxo-1,2-benzisothiazole-1, 1-dioxide의 몇몇 유도체를 합성하고 이들 유도체의 Pyricuria oryzae에 대한 항균성을 조사하였다. 이들 유도체의 $I_{50}$값은 각각 다음과 같다 ; 3-chloro (37.8ppm), 2-chloro (318.7ppm), MCS (20.1ppm), 3-(P-nitrophenyloxy) (35.4ppm), 3-(o-nitrophenyloxy) (11.8ppm), 3-(p-aminophenyloxy) (1643.2ppm) 2-allyl (946.2ppm), 2-(hydroxymethyl) (248.4), 2-chloromethyl 유도체 (192.7ppm)
Some derivatives of 3-oxo-1,2-benzisothiazole-1,1-dioxide were synthesized, and their antifungal activities against Pyricularia oryzae was determined by the agar medium dilution method. $I_{50}$ values of the candidate derivatives were shown to be as follows; 3-chloro(37.8ppm), 2-chloro(318.7ppm), MCS(20.1ppm), 2-allyl(946.2ppm), 3-(p-nitrophenyloxy) (35.4ppm), 3-(o-nitrophenyloxy) (11.8ppm), 3-(p-aminophenyloxy) (1643.2ppm), 2-chloromethyl(192.7ppm) and 2-hydroxymethyl derivative(248.4ppm).
