The ethyl acetate fraction of Artemisia dubia showed a potent inhibitory activity on recombinant hnman AKR1B10 (rh AKR1B10). Due to its potency, subsequent purification of ethyl acetate fraction led to seven compounds including five dicaffeoylquinic acid (DCQA) derivatives. Compounds were identified as 3,4-dibydroxybenzoic acid (1), quercetin 3-O-${eta}$-glucose (2), 3,4-DCQA (3), 3,5-DCQA (4), 4,5-DCQA (5), 3,5-DCQA methyl ester (6), and 4,5-DCQA methyl ester (7). A series of DCQA derivatives (3-7) showed inhibitory activity on rhAKR1B10 in the range of $IC_{50}$ $1.24-2.29;{mu}M$, whereas 3,4-dihydroxybenzoic acid and quercetin 3-O-${eta}$-glucose showed no inhibitory activity on rhAKR1B10.