The study of the osteoinductive effect during the
implantation in the bone defect area has been carried
out, also the bone morphogenetic protein(BMP) has
been taken notice of osteoinduction material. Urist
(1965) was the first to report the presence of bone
morphogenetic protein (BMP) that was detected by
transplantation of decalcified bone matrix into an
intramuscular site, where it induced ectopic
ossification. The term “bone morphogenetic
protein”(BMP) was introduced to describe the
substance(s) in the demineralized bone matrix
responsible for the phenomenon.