The purpose of this study was to evaluation the effects of 12 weeks walking exercise program participation on changes of insulin resistance and peripheral artery in diabetic patients. Thirty-one overweight women with type 2 diabetes were randomly assigned to control groups(CG, N=15), walking exercise program groups(WEPG, N=16). Walking exercise program was performed 4 times a week at the intensity of 55-60% HRmax(1-4 weeks; 55% HRmax, 5-8 weeks; 60% HRmax, 8-12 weeks; 65% HRmax). The ankle-brachial index (ABI)was used to assess peripheral arterial disease(PAD). The data from this study were analyzed using repeated measures two-way ANOVA. The following conclusions were obtained by comparing and analyzing the measurement value pre and post of walking exercise program. In the change of BMI, HOMA-IR, the walking exercise group was significantly improved more than control group and pre exercise data(p<.05). But plasma hs-CRP level and ABI showed no significant. Therefore, walking exercise program enough to result in significant weight and fat reduction did not ameliorate inflammation and ABI as measured at the end of a 12-week walking exercise intervention. These results suggest that 12 weeks walking exercise program could be helpful to reduce blood glucose by improving insulin resistance in type 2 diabetic patients.